Microbiota News
Structured summaries of the scientific literature, updated daily.
Scoping review: microbiome-driven precision psychiatry along the gut-brain axis
Across 28 predominantly observational studies, gut microbiome biomarkers for depression and anxiety show early biologica…
Gut microbiota and lung injury (2015–2026): bibliometric and visualization analysis
Scientific output on gut microbiota and lung injury increased sharply after 2019, but the field remains dominated by mec…
Meta-analysis of probiotic/synbiotic interventions in metabolic syndrome: preclinical and clinical evidence
Probiotics/synbiotics improve body weight, waist circumference, and lipid profile in metabolic syndrome patients, but do…
Multi-omics profiling reveals microbiota-gut-brain axis dysregulation in an LPS-induced model of sepsis-associated encephalopathy
In LPS-exposed zebrafish, disruption of the microbiota-gut-brain axis is associated with SAE-like neurobehavioral abnorm…
Gut microbiomes, host immune response, and organ dysfunction across the gut-lung, gut-brain, and gut-liver axes
This narrative review synthesizes mechanistic associations between gut dysbiosis and distant-organ dysfunction but estab…
Reproductive Tract Microbiome, Infertility, and ART: Comprehensive Narrative Review
This narrative review associates non-Lactobacillus-dominant endometrial profiles with worse implantation and ART outcome…
Quercetin in bladder cancer: synergistic regulation of gut microbiota and L-serine metabolic pathway
In murine bladder cancer models, quercetin inhibited tumor progression by modulating gut microbiota and suppressing de n…
Microbiota and perimenopausal syndrome: mechanisms and therapeutic strategies (narrative review)
No reproducible gut dysbiosis pattern specific to perimenopausal syndrome has been established.
Quercetin as a dual metabolic reprogramming agent in bladder cancer: exogenous blockade via microbiota and endogenous blockade via PSPH
In preclinical models, quercetin reduced L-serine availability in bladder cancer cells through two simultaneous mechanis…
Lactobacillus rhamnosus Lysate for MASLD: A Randomized Controlled Trial
Twelve weeks of L. rhamnosus DV-NRRL B-68023 lysate reduced biochemical steatosis indices, transaminases, and inflammato…
Gut E. coli–Collinsella signature associated with Wagner 4 gangrenous diabetic foot ulcers
A three-MAG gut metagenomic signature — enriched E. coli and depleted Collinsella — distinguishes gangrenous diabetic fo…
Berberine and MASLD: global bibliometric analysis with molecular mechanism review
A dual-database bibliometric study mapped 341–624 publications on berberine in MASLD and identified four dominant themat…
The Rhizosphere Microbiome as a Mediator of Crop Responses to Fertilization Strategies
This narrative review synthesizes evidence that different fertilization strategies alter rhizosphere microbiome structur…
Cross-model metabolomic signatures of dietary anti-inflammatory polyphenols in nutraceutical development: a systematic review
This systematic review maps metabolomic signatures of dietary polyphenols across multiple models, but the submitted text…
Optimizing rhizosphere metabolic circular economy toward sustainable ecosystems
This perspective article proposes an expanded conceptual framework for the Rhizosphere Metabolic Circular Economy (RMCE)…
Protocol for a randomised, double-blind, placebo-controlled trial assessing Enterosgel® for functional abdominal pain in children (ENTOPIC)
This document is a study protocol — no efficacy or safety data have been collected or analysed; effect direction is insu…
Bacteriocins and postbiotics as anticancer agents: narrative review of mechanisms and translational opportunities
Narrative review indicates that microbiome-derived bacteriocins and postbiotic metabolites exert anticancer effects in p…
Recurrent UTI: beyond infection — the ecological puzzle
This narrative review reframes recurrent UTI as a multifactorial ecological phenomenon — involving microbiota, host immu…
Gut dysbiosis in gynecological diseases associated with female infertility: a scoping review
This scoping review maps associations between gut dysbiosis and PCOS/PMOS, endometriosis, and uterine fibroids, but esta…
Low-FODMAP diet reduces Bifidobacterium in IBS patients: direction-of-effect consistency analysis across 12 RCTs
The low-FODMAP diet consistently reduces Bifidobacterium abundance in IBS patients (9 of 11 studies, p=0.033), while its…
Lysine acylation in the hepatic immune microenvironment of MASLD: mechanistic review
This narrative review maps how lysine acylation modifications (lactylation, succinylation, malonylation, β-hydroxybutyry…
Ling-Gui-Zhu-Gan Decoction in MASLD: integrated gut microbiota and lipidomics study in an animal model
In high-fat diet-induced MASLD rats, LGZGD treatment reduced serum and hepatic lipid and liver enzyme markers and modula…
Multidimensional iron dysmetabolism and gut-brain axis interactions in restless legs syndrome: from peripheral deficiency to central dysregulation
This narrative review proposes a multilevel iron metabolism dysfunction in RLS — from intestinal absorption to BBB trans…
Ex vivo fermentation-guided dietary fiber personalization increases fecal volatile fatty acid production: a proof-of-concept crossover trial
Dietary fiber selection guided by individual ex vivo fermentation capacity (MyDFF platform) favored fecal volatile fatty…
Maternal dietary fiber, short-chain fatty acids, and offspring developmental programming: a narrative review
This review synthesizes mechanisms by which maternal fiber-derived SCFAs modulate offspring metabolic and immune program…
Synbiotic HQP08 Supplementation for Hair Loss and Depressive Symptoms: An Open-Label Pilot Study of Clinical Outcomes and Gut Microbiome Changes
In 32 adults without a control group, synbiotic HQP08 (B. longum HK003) yielded self-reported hair loss improvement in 6…
Probiotic supplementation and performance during detraining and post-EIMD recovery in college volleyball players: exploratory RCT
Eight weeks of multi-strain probiotics showed a favorable direction of effect on isometric strength retention and post-e…
Tryptophan metabolism and plant health: mechanisms of action and application prospects
This narrative review maps tryptophan metabolic pathways in plants and microorganisms and proposes a theoretical immunor…
Early-life gut microbiota and the pediatric gut-lung axis: systematic review of clinical, preclinical, and mechanistic evidence
This systematic review finds consistent associations between early gut dysbiosis and worse pediatric respiratory outcome…
Cascading effects of combining acid suppressants with anti-tuberculosis therapy on the microbiome and clinical outcomes: narrative review
Combining acid suppressants (especially PPIs) with anti-tuberculosis drugs exacerbates gut dysbiosis through a dual inde…
Modulating the Gut-Ovarian Axis: Mechanistic Rationale and the Limits of Current Evidence for Probiotics in Female Reproductive Aging
No randomized human trial has demonstrated that probiotic interventions slow the longitudinal physiological loss of ovar…
Microbial metabolism and CAR-T cell fitness: a metabolome-centered translational framework
This narrative review proposes that microbiota-derived metabolites — SCFAs, indoles, and inosine — modulate CAR-T cell f…
MASLD beyond the liver: decoding the gut-genetic-metabolic nexus
This narrative review maps gut-liver axis mechanisms in MASLD but generates no new causal evidence and does not support …
Age-specific alterations in gut microbiota–plasma metabolome networks in first-episode, drug-naïve major depressive disorder: adolescents versus adults
Adolescents and adults with first-episode, drug-naïve MDD display distinct, non-overlapping gut dysbiosis and plasma met…
Lactiplantibacillus pentosus CECT 8039 attenuates weight gain and adipokine markers in a murine diet-induced obesity model
In HFD-fed mice over 28 days, L. pentosus BB supplementation was associated with 13.2% lower relative body-weight gain a…
Gut microbiome-mediated primary and acquired resistance to immune checkpoint inhibitors in MSI-H/dMMR colorectal cancer: narrative review
A narrative review maps mechanisms, biomarkers, and therapeutic strategies through which the gut microbiome may mediate …
Gut microbiota and SCFAs as predictors of postoperative infection site in neurocritical care patients
A six-genus fecal microbial panel collected within 24 h post-surgery discriminated pulmonary from intracranial infection…
Sishen Wan modulates gut microbiota and short-chain fatty acids in a murine chronic sleep deprivation model
In a murine chronic sleep deprivation model, high-dose Sishen Wan favored behavioral, inflammatory, and microbiota outco…
Plasma TMAO and atherosclerotic cardiovascular disease: meta-analysis of case-control studies
Elevated plasma TMAO levels are associated with increased ASCVD risk (OR = 1.39; 95% CI: 1.21–1.61), particularly in pri…
Lung-gut-brain axis in NSCLC: narrative review with systematic search of three signaling pathways
Evidence favors a role for soluble microbial metabolites (SCFAs, tryptophan, bile acids) in NSCLC immune modulation, whi…
Engineered bacteria and engineered probiotics for intestinal disease therapy: bibliometric and knowledge mapping analysis
Scientific output on engineered bacteria and probiotics for intestinal disease grew continuously from 2015 to 2025, with…
Microbiome–nitric oxide axis in cancer immunotherapy: a qualitative systematic review
The review identified clinical associations between gut microbiome composition and ICI outcomes but found no direct evid…
Probiotics against candidiasis: systematic review of experimental and mechanistic evidence
Probiotics show consistent anti-Candida activity in predominantly in vitro models, but clinical evidence in humans is in…
Gut microbiota and adaptive immunity in type 2 diabetes: mechanisms, progression, and therapeutic strategies
This narrative review maps bidirectional interactions between gut microbiota and adaptive immunity in T2DM but provides …
Resistance training with aerobic active recovery in obesity and metabolic syndrome: narrative review and protocol proposal
No randomized chronic intervention trial directly evaluating resistance training with aerobic active recovery exists for…
Therapeutic modulation of the gut-brain axis in alcohol use disorder: a systematic review
Gut-brain axis interventions (FMT, probiotics, prebiotics, GLP-1 agonists) show a favorable direction in behavioral and …
Ketogenic diet combined with probiotics for PCOS/PMOS: narrative review from the gut microbiota–host metabolic axis perspective
This narrative review proposes mechanistic rationale for combining ketogenic diet and probiotics in PCOS but presents no…
Gut microbiota-derived metabolites and multi-organ fibrosis: mechanisms, cross-organ signatures, and therapeutic opportunities
This narrative review maps associations between gut dysbiosis and multi-organ fibrosis but provides no primary data suff…
Gut microbiota and metabolomics in degenerative rotator cuff tendinopathy: a case-control study
Patients with symptomatic degenerative rotator cuff tendinopathy show gut dysbiosis with enrichment of pro-inflammatory …
Heat-killed postbiotic beLP1® reduces gastrointestinal symptoms in adults with excess weight: randomized controlled trial
beLP1® produced a statistically significant, favorable reduction in total GSRS scores compared to placebo at days 42 and…
Antibiotic-induced gut microbiota dysbiosis in the PICU: mechanisms, clinical outcomes, and management strategies — narrative review
Antibiotic exposure occurs in 58–94% of PICU children and is the primary modifiable driver of gut dysbiosis, but evidenc…
Gut microbiota in Graves' disease: mechanisms and clinical implications (narrative review)
This narrative review describes associations between gut dysbiosis and Graves' disease but does not establish causality …
Microbiome and Checkpoint Inhibitors in Hepatocellular Carcinoma: Mechanistic Review
This narrative review synthesizes preclinical and emerging clinical evidence on how the gut microbiome modulates checkpo…
Microbiota-mitochondria axis in neurodegenerative disorders and retinal dysfunction: mechanisms and emerging therapeutic opportunities
This narrative review does not establish causality or effect magnitude between the microbiota-mitochondria axis and neur…
Passiflora incarnata leaf polyphenol extract attenuates high-fat-diet-induced metabolic syndrome in mice via the gut-liver-adipose axis
In C57BL/6J mice fed a high-fat diet, oral supplementation with P. incarnata polyphenol extract favored reductions in bo…
Eucommia ulmoides leaf polyphenols reduce blood pressure and modulate gut microbiota in spontaneously hypertensive rats
EULP (1.25–3.75 mL/kg/day, 4 weeks) favorably reduced systolic blood pressure in SHR rats compared to the model group, w…
TMAO and Homocysteine: Distinct Metabolic Origins, Shared Renal Determinants and Pathophysiological Pathways in Kidney Disease
This narrative review establishes that TMAO and homocysteine accumulate in chronic kidney disease through distinct mecha…
Physiological Adaptation to Plant-Based Diets: A Homeostatic Framework for Sustained Dietary Change
This narrative review argues that plant-based diets elicit measurable homeostatic adaptations (iron, protein, microbiota…
Fatty acid profiles of transition milk in Czech Fleckvieh cows milked by automatic milking system: effects of parity and milking number
Milking number and parity significantly alter the fatty acid profile of transition milk, while milking interval exerts m…
Gut-Brain Axis and Dietary Patterns in Adolescent and Young Adult Childhood Cancer Survivors: A Systematized Narrative Review
This systematized narrative review maps hypothetical pathophysiological mechanisms between treatment-induced dysbiosis a…