Profiling lung and gut microbiomes in COPD: ontology-based evidence synthesis
An ontology-driven systematic review of over 30 studies identified more than 100 significantly altered bacterial taxa in the airways and gut of COPD patients.
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What the study showed
Airway microbiome analysis showed expansion of pathogenic genera including Haemophilus, Moraxella, Pseudomonas, and Burkholderia, with species-level confirmation of H. influenzae and P. aeruginosa enrichment. Gut microbiome profiles showed depletion of SCFA-producing anaerobes such as F. prausnitzii, B. bifidum, and members of Lachnospiraceae and Ruminococcaceae across three clinical conditions.
How it was done
Authors developed the O-ESR pipeline using the Ontology of Host-Microbiome Interactions (OHMI) framework to standardize integration of data from over 30 COPD microbiome studies.
Risk of bias
Only the abstract is available; selection criteria, risk of bias assessment, and statistical pooling methods cannot be evaluated. Heterogeneity among primary studies is acknowledged but its handling is not described in the abstract.
What this study does NOT prove
The study does not demonstrate that dysbiosis causes COPD or that microbiome modulation improves clinical outcomes.
In clinical practice
Findings consolidate known dysbiosis associations in COPD but do not establish causality. No clinical intervention is supported by this evidence alone.
Limitations
Only the abstract is available; selection criteria, risk of bias assessment, and statistical pooling methods cannot be evaluated. Heterogeneity among primary studies is acknowledged but its handling is not described in the abstract.
Technical appendix
Version history
- 1.0 · 2026-06-26 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.