Polyphenols, gut microbiota and cognitive function: a narrative review
A narrative review examines the role of polyphenols in cognition and dementia through gut-microbiota-brain axis modulation.
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What the study showed
The abstract reports that polyphenols exert neuroprotective effects via antioxidant and anti-inflammatory activity. Gut microbiota metabolizes polyphenols into bioactive molecules that may influence the central nervous system. A reciprocal regulation between microbiota composition and polyphenol-induced brain effects is described.
How it was done
Narrative literature review covering January 2000 to February 2026, searching PubMed, Scopus, Web of Science, and ClinicalTrials.gov using predefined terms.
Risk of bias
Narrative reviews are prone to selection bias and lack systematic evidence synthesis protocols. Access limited to the abstract prevents evaluation of inclusion criteria, study quality, and population heterogeneity.
What this study does NOT prove
This study does not establish causality between polyphenol intake and reduced dementia risk in humans.
In clinical practice
This abstract provides insufficient grounds to recommend polyphenol supplementation clinically for dementia prevention. Narrative reviews generate hypotheses, not guidelines.
Limitations
Narrative reviews are prone to selection bias and lack systematic evidence synthesis protocols. Access limited to the abstract prevents evaluation of inclusion criteria, study quality, and population heterogeneity.
Technical appendix
Version history
- 1.0 · 2026-09-01 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.