Oxidative Stress and Gut-Skin Axis Dysbiosis in Immune-Mediated Skin Disorders: Narrative Review
Elevated oxidative biomarkers and gut dysbiosis are consistently reported across major immune-mediated dermatoses, but causality remains unestablished.
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What the study showed
The review maps evidence on ROS pathways, lipid peroxidation, ferroptosis, and gut-skin microbiome dysbiosis in conditions such as psoriasis and atopic dermatitis. Biomarkers including MDA, AGEs, AOPPs, and 8-OHdG are consistently elevated. Depletion of SCFA-producing taxa (Faecalibacterium prausnitzii, Bifidobacterium, Akkermansia muciniphila) is a recurrent finding.
How it was done
Narrative review without a registered systematic protocol; synthesizes existing literature on oxidative mechanisms and microbiome involvement in immune-mediated skin diseases.
Risk of bias
Narrative design carries non-systematic study selection and high publication bias risk; no quantitative synthesis or inclusion criteria are reported in the abstract.
What this study does NOT prove
Does not prove that correcting oxidative stress or modulating the microbiome treats or prevents any immune-mediated skin disorder.
In clinical practice
No clinical intervention can be recommended based on this review. Findings support hypothesis generation for future trials, not practice change.
Limitations
Narrative design carries non-systematic study selection and high publication bias risk; no quantitative synthesis or inclusion criteria are reported in the abstract.
Technical appendix
Version history
- 1.0 · 2026-08-19 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.