Heat-treated Lactiplantibacillus plantarum LM1004: microbiome modulation and NK cell activity in a randomized clinical trial
Eight weeks of HT-LM1004 supplementation significantly increased NK cell activity and white blood cell counts compared to placebo.
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What the study showed
The randomized, placebo-controlled clinical trial showed statistically significant improvements in NK cell activity and total leukocyte counts after 8 weeks of supplementation. In a simulated human intestinal microbiome ecosystem, HT-LM1004 increased microbial species diversity in the ascending colon and selectively enriched low-abundance beneficial bacterial taxa. Metabolomics revealed compartment-specific changes in bile acid metabolism pathways and distinct, time-dependent SCFA profiles across gut compartments.
How it was done
Randomized, placebo-controlled clinical trial with 8 weeks of HT-LM1004 supplementation. Mechanistic studies were conducted using an in vitro simulated human intestinal microbiome ecosystem with metabolomics and SCFA profiling.
Risk of bias
The abstract does not report sample size, participant characteristics, or detailed primary endpoints, precluding assessment of statistical power. Mechanistic data derive from an in vitro simulated model, limiting direct extrapolation to human physiology.
What this study does NOT prove
It cannot be concluded that HT-LM1004 prevents infections, disease, or produces measurable clinical benefits in specific populations.
In clinical practice
Findings do not support immediate clinical recommendation; full publication and independent replication are required before any clinical application.
Limitations
The abstract does not report sample size, participant characteristics, or detailed primary endpoints, precluding assessment of statistical power. Mechanistic data derive from an in vitro simulated model, limiting direct extrapolation to human physiology.
Technical appendix
Version history
- 1.0 · 2026-07-24 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.