Gut reservoir of carbapenem-resistant Enterobacterales: from dysbiosis and colonization to infection and decolonization in hematologic malignancy patients
This narrative review synthesizes evidence linking gut dysbiosis to CRE colonization persistence and invasive infection, with emphasis on hematologic malignancy patients.
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What the study showed
Intestinal colonization by CRE is increasingly identified as the key precursor to invasive infections in immunocompromised hosts. Reduced microbial diversity, depletion of beneficial anaerobes, epithelial barrier dysfunction, and immune dysregulation facilitate CRE persistence. Emerging decolonization strategies including FMT, phage therapy, and CRISPR-based approaches are reviewed alongside conventional methods.
How it was done
Narrative review design; no systematic protocol, explicit search strategy, or inclusion criteria are described in the available abstract.
Risk of bias
Narrative reviews are inherently prone to selection bias and cannot support quantitative synthesis. The abstract provides no detail on study quality assessment or heterogeneity of included evidence.
What this study does NOT prove
This review does not demonstrate efficacy of any decolonization strategy through controlled clinical trials, nor does it establish causality between dysbiosis and CRE infection.
In clinical practice
Emerging microbiome-targeted interventions lack robust clinical trial evidence in hematologic populations; no practice change should be inferred from this review alone.
Limitations
Narrative reviews are inherently prone to selection bias and cannot support quantitative synthesis. The abstract provides no detail on study quality assessment or heterogeneity of included evidence.
Technical appendix
Version history
- 1.0 · 2026-09-05 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.