Efficacy and safety of H. pylori eradication therapy in real-world clinical practice: results of the PAMIR observational program
A Russian real-world observational program assessed H. pylori eradication with standard triple therapy and augmented regimens in 870 duodenal ulcer patients.
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What the study showed
The abstract describes 912 H. pylori-positive patients receiving triple therapy (omeprazole, clarithromycin, amoxicillin) alone or combined with bismuth, rebamipide, and/or a probiotic synbiotic complex. Gastrointestinal symptoms were measured using the GSRS questionnaire and satisfaction via Likert scales. Eradication was confirmed by validated methods, but numerical eradication rates are absent from the available abstract excerpt.
How it was done
Prospective observational program in real-world clinical practice; 870 patients completed the study, divided into a standard PAM group (n=538) and an augmented PAMplus group (n=332). Post-treatment eradication was assessed by 13C-urea breath test, stool antigen test, or rapid urease test.
Risk of bias
Non-randomized observational design without a control group precludes causal inference between treatment regimens and outcomes. The abstract is truncated and lacks eradication rates and complete safety data, preventing quantitative appraisal.
What this study does NOT prove
The truncated abstract does not allow any conclusion about the superiority of any tested regimen in eradication rates or safety profile.
In clinical practice
Available data are insufficient to modify clinical practice beyond current H. pylori eradication guidelines. The role of bismuth and probiotics as adjuncts to triple therapy remains supported by other evidence, not by this incomplete abstract.
Limitations
Non-randomized observational design without a control group precludes causal inference between treatment regimens and outcomes. The abstract is truncated and lacks eradication rates and complete safety data, preventing quantitative appraisal.
Technical appendix
Version history
- 1.0 · 2026-08-24 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.