EAT-IT sustainable dietary pattern: pilot crossover RCT in 9 participants
In 9 young adults, 6 weeks on the EAT-IT pattern reduced fasting insulin and HOMA-IR within the group, without statistically robust between-group comparisons.
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What the study showed
The EAT-IT pattern significantly increased fiber and ω-6 fatty acid intake versus the control diet. Within-group reductions in fasting insulin and HOMA-IR were observed. Gut microbiota shifts included increased Bacteroides and decreased Coriobacteriaceae.
How it was done
Pilot randomized controlled crossover trial with 9 subjects (mean age 26 years), 6 weeks per intervention, comparing EAT-IT against Italian Food-Based Dietary Guidelines; 7-day food records, metabolic parameters, and 16S rRNA gut microbiota sequencing.
Risk of bias
N=9 is insufficient for confirmatory inference; without the full text, randomization sequence, washout period, and intention-to-treat analyses cannot be assessed. Metabolic reductions are within-group only.
What this study does NOT prove
Does not prove that the EAT-IT pattern is superior to Italian dietary guidelines for glycemic control or microbiota modulation.
In clinical practice
Pilot data with a minimal sample do not support clinical recommendations. Results are useful only for sample size estimation in future trials.
Limitations
N=9 is insufficient for confirmatory inference; without the full text, randomization sequence, washout period, and intention-to-treat analyses cannot be assessed. Metabolic reductions are within-group only.
Technical appendix
Version history
- 1.0 · 2026-07-07 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.