Decolonisation of multidrug-resistant E. coli and vancomycin-resistant E. faecium following faecal microbiota transplantation
A single case report describes decolonisation of two multidrug-resistant pathogens via capsulated FMT, followed by acquisition and subsequent clearance of ESBL-producing K. pneumoniae after a second FMT course.
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What the study showed
The abstract reports elimination of ESBL-producing E. coli and vancomycin-resistant E. faecium following capsulated FMT. The patient subsequently acquired ESBL-producing K. pneumoniae, which was cleared after a second round of FMT. Six distinct carbapenemase-producing organisms were also detected in this patient.
How it was done
Single case report of a patient evacuated from the war in Ukraine, treated with two separate courses of capsulated FMT. No control group or comparator is described.
Risk of bias
Single case report with no control, no generalisability, and high risk of reporting bias. The abstract provides no detail on microbiological follow-up protocol, donor selection, or decolonisation criteria.
What this study does NOT prove
Efficacy of FMT for decolonisation of multidrug-resistant organisms in broader patient populations cannot be concluded.
In clinical practice
Evidence from a single case does not support changes in clinical practice. FMT for decolonisation of multidrug-resistant organisms remains experimental.
Limitations
Single case report with no control, no generalisability, and high risk of reporting bias. The abstract provides no detail on microbiological follow-up protocol, donor selection, or decolonisation criteria.
Technical appendix
Version history
- 1.0 · 2026-07-13 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.