Dealcoholized muscadine wine improved skin elasticity and oxidative stress biomarkers without affecting gut microbiome in women over 40
Daily intake of 300 mL dealcoholized muscadine wine for 6 weeks improved selected skin elasticity parameters and reduced MMP-9 and advanced glycation end products in healthy women, with no detectable effect on the gut microbiome.
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What the study showed
Dealcoholized muscadine wine reduced transepidermal water loss and increased facial and forearm elasticity compared to placebo. Plasma biomarkers of oxidative stress and inflammation (MMP-9 and AGEs) decreased significantly. Gut microbiome abundance, diversity, and functions were unaffected by the intervention.
How it was done
Single-blind randomized crossover trial: 17 healthy women consumed 300 mL/day of DMW or placebo for 6 weeks, separated by a 3-week washout. Fecal microbiome was assessed by shotgun sequencing.
Risk of bias
A sample of 17 participants is too small for generalization; single-blind design limits bias control. Absence of data on habitual diet, hormonal status, or skin phototype prevents adjustment for relevant confounders.
What this study does NOT prove
The study does not prove that dealcoholized muscadine wine prevents skin aging or meaningfully modifies the gut microbiome.
In clinical practice
Findings do not support clinical recommendations. Insufficient sample size and short duration preclude robust inferences about real skin health benefits.
Limitations
A sample of 17 participants is too small for generalization; single-blind design limits bias control. Absence of data on habitual diet, hormonal status, or skin phototype prevents adjustment for relevant confounders.
Technical appendix
Version history
- 1.0 · 2026-09-05 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.