Correction to precision synbiotic RCT (2'-FL + Bifidobacterium) in toddlers
This document is solely an editorial correction of typographical errors in methods and discussion; it does not alter any findings, effect direction, or conclusions of the original RCT.
| Population | Healthy toddlers, multicenter trial, n=390, allocated 1:1:1 |
|---|---|
| Intervention | Synbiotic: 2'-FL 1.0 g/day + B. infantis R0033 1.5×10⁹ CFU/day + B. bifidum R0071 1.5×10⁹ CFU/day (HPG) |
| Comparator | Isolated group (IG) and placebo control group (CG) |
| Outcome | Editorial correction (no new clinical outcome) |
Summary of findings
| Outcome | Effect | 95% CI | Certainty | Clinical relevance | Notes |
|---|---|---|---|---|---|
| Editorial correction (no new clinical outcome) | not applicable | — | Very low | — |
Context
The original article investigated a synbiotic intervention (2'-FL + B. infantis R0033 + B. bifidum R0071) in healthy toddlers on immune and disease outcomes. Editorial corrections affect only the dose description (CFU per strain) and one paragraph of limitations; primary data remain unchanged. Clinicians who cited the original article should update their reference to the corrected version.
What the study showed
This correction document reports no new data and does not alter any results from the original article. The three amendments correct: (1) CFU dose per strain in the abstract, (2) corresponding text in the methods section (Section 2.4), and (3) one limitations paragraph in Section 5. No effect estimates, 95% CIs, or p-values were modified.
How it was done
Editorial correction published by Frontiers in Nutrition (DOI: 10.3389/fnut.2026.1957323). The original RCT was multicenter, double-blind, placebo-controlled, three-arm, n=390 healthy toddlers, randomized 1:1:1. Duration and other methodological parameters are not altered by this correction.
Effect magnitude
No new effect sizes are reported in this document. The correction does not modify any quantitative estimates from the original article.
Risk of bias
The correction makes explicit an already acknowledged limitation: a fixed dose of 1.5×10⁹ CFU/day per strain precludes evaluation of optimal dose-response for prevention of respiratory, gastrointestinal, and allergic diseases. The risk-of-bias tool used in the original study is not reassessed in this document. Critical appraisal of the RCT requires access to the corrected full-text version.
What this study does NOT prove
This document neither proves nor refutes any clinical efficacy of the synbiotic; it is exclusively an editorial erratum. No causal or efficacy inference can be drawn from this correction.
In clinical practice
Clinicians should cite the corrected version of the original article. Correct doses are: 2'-FL 1.0 g/day + B. infantis R0033 1.5×10⁹ CFU/day + B. bifidum R0071 1.5×10⁹ CFU/day. Clinical decisions must not be based solely on this correction document.
Limitations
The correction makes explicit an already acknowledged limitation: a fixed dose of 1.5×10⁹ CFU/day per strain precludes evaluation of optimal dose-response for prevention of respiratory, gastrointestinal, and allergic diseases. The risk-of-bias tool used in the original study is not reassessed in this document. Critical appraisal of the RCT requires access to the corrected full-text version.
What is still missing
The original article acknowledges the need for dose-response studies for B. infantis R0033 and B. bifidum R0071 on respiratory, gastrointestinal, and allergic outcomes in toddlers.
Technical appendix
Version history
- 1.0 · 2026-11-11 — Auto-generated under Evidence Standard v1.0