Clinical Efficacy of the Postbiotic Biodonatum in Children with Pneumonia and Reduced Antibiotic Sensitivity
A pediatric RCT evaluates Biodonatum as an adjunct to antibiotic therapy in community-acquired pneumonia with documented resistance.
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What the study showed
The abstract describes a randomized controlled trial testing a postbiotic preparation (Biodonatum) added to standard antibiotic therapy in children with pneumonia showing reduced susceptibility to first-line agents. No numerical results are disclosed in the abstract — only study design, population, and assessed outcomes are reported. Clinical, laboratory, and microbiological parameters were measured at baseline, day 7, and day 14.
How it was done
Prospective RCT enrolling 90 children (ages 3–14), randomized into two equal groups (n=45 each): intervention (Biodonatum plus standard antibiotic) versus control (standard antibiotic alone), conducted at Tashkent State Medical University.
Risk of bias
The abstract provides no outcome data, effect sizes, p-values, or confidence intervals, making it impossible to assess the magnitude or significance of findings. The journal (IJMSCR) is not indexed in high-impact databases, and Biodonatum is absent from established reference literature, raising concerns about study independence.
What this study does NOT prove
The abstract alone does not demonstrate efficacy, safety, or microbiome effects of Biodonatum.
In clinical practice
Without access to results, any clinical recommendation would be premature. Full-text review is mandatory before any consideration of clinical use.
Limitations
The abstract provides no outcome data, effect sizes, p-values, or confidence intervals, making it impossible to assess the magnitude or significance of findings. The journal (IJMSCR) is not indexed in high-impact databases, and Biodonatum is absent from established reference literature, raising concerns about study independence.
Technical appendix
Version history
- 1.0 · 2026-08-22 — Auto-generated under Evidence Standard v1.0
Paid access: structured summary from public metadata; consult the original study at the source.